Enrique Izaguirre, PhD, DABR, is an internationally-recognized medical physicist expert in image guided radiation therapy; in vivo treatment monitoring for intensity modulated radiation therapy and stereotactic body radiotherapy; specialized treatment modalities such as radiosurgery and total body radiotherapy; and multimodality image guided brachytherapy.
Dr. Izaguirre brings to West Cancer Center extensive experience in medical physics from the laboratory bench to the clinical practice.
Titles and Roles
- Director of the Medical Physics Program, Department of Radiation Oncology, West Cancer Center
- Associate Professor of Biophysics, The University of Tennessee Health Science Center
- Associate Professor of Radiation Oncology, The University of Tennessee Health Science Center
Areas of Expertise
- Image guided radiation therapy. Multimodality imaging, SPECT, PET, and CT
- Real time patient specific and treatment delivery quality assurance
- Preclinical Instrumentation; micro irradiation, SPECT, PET, and CT
- Biophysics of ionizing radiation, and drug uptake and transport
- Intensity modulated radiation therapy, stereotactic radiation surgery, and stereotactic body radiation therapy.
- Total body irradiation
Through the implementation of advanced strategies to deliver more accurate and precise treatments, Dr. Izaguirre brings to West Cancer Center the expertise to implement a variety of advanced treatment modalities for patients undergoing radiation therapy. His medical physics work focus on specialized care for patients requiring highly conformal irradiation (IMRT, SRS and SBRT), and advanced imaging modalities for malignancy visualization and motion management (4D imaging, gated radiotherapy). He has extensive experience in developing and implementing new technologies to deliver new treatment protocols requiring specialized algorithms and techniques such as CT-MRI guided HDR, SRS (linac and gamma knife), SBRT, melanoma, skin cancer (electron and HDR), and total body irradiation for bone marrow transplantation.
Dr. Izaguirre has experience in the implementation of clinical trials data evaluation and to commission the required technology (IMRT, SBRT) for lung and gastric cancer.
He is a member of American Association of Medical Physicist IMRT study group, an international recognized group of experts who evaluate new technology and protocols and establish the guidelines for the clinical implementation and the advancement of highly conformal radiation therapy techniques such as IMRT, VMAT, and gated-VMAT.
As researcher, Dr. Izaguirre is a world-recognized scientist in the field of preclinical imaging and micro irradiation. He developed the first solid state microSPECT-micro CT and the first dual gantry micro irradiator, the microIGRT. Both technologies are currently used for the evaluation of novel therapies for cancer treatments. He brought to the field of cell microirradiation the real time image guidance concept to acquire correlated microbeams profiles and images of fluorescent labeled cell organelles.
A leading scientist in real time clinical imaging instrumentation and dosimeters, his team developed the first in vivo real time treatment monitoring system for IMRT and SBRT radiotherapy. For his research activities, he has received grants from the National Institute of Health, and he has being invited to international conferences such and the Nobel Academy of Sciences Imaging conference, SPIE medical imaging and the AAMP annual meeting.
Education and Training
Dr. Enrique W. Izaguirre graduated from The University of Buenos Aires, Argentina, from the college of Exact and Natural sciences with a master’s degree in physical sciences. He continued his studies at Drexel University, Philadelphia, where he graduated with a master’s degree in Physics and a doctoral degree in Physics in the quantum optics specialty. His postdoctoral education was at the W.M. Keck Center for Molecular Electronics, Syracuse University, where he specialized in Molecular and Bimolecular Electronics and at the University of California San Francisco, School of Medicine, where he specialized in clinical and preclinical instrumentation development, and multimodality anatomical and functional imaging for clinical and preclinical applications. After several years of research at the frontier of physics and biology, he moved to St. Louis, where he completed a medical physics residency at the University of Washington in St. Louis, School of Medicine.
Dr. Izaguirre awards include the University of Buenos Aires competitive research award; awards from multiple institutions that supported his education, such as the Antorcha Foundation Fellowship for Studies Abroad; the Doctoral Fellowship from the National Science Committee of Argentina Republic, Fellowship for Science; Foundation of Neuquen Bank, Argentina; and the Graduate and research Fellowship, Drexel University, Philadelphia. He also received the BMCC CUNY President Technology Award and BMCC CUNY Award for development and incorporation of new technology in Science Courses. Dr. Izaguirre received grants from the National Institute of Health, WashingtonUniversity, and The Baylor Scott and White foundation.
Dr. Izaguirre is directing the biophysics laboratory and the medical physics division research efforts.
The specific areas of study are:
- Development of novel clinical detectors and algorithms to advance external beam radiotherapy.
- Evaluation of new cancer drugs in micro devices designed to study combined chemo-radiotherapy biophysical processes and transport.
- Radiotherapy preclinical trials
To learn more about the biomedical physics laboratory and the medical physics division research efforts, click here.
Dr. Izaguirre has published more than 20 peer reviewed articles covering fundamental research in physics; biophysics and applied research in translational biophysics; medical physics; and radiation therapy. He has more than 50 published abstracts in the areas of preclinical and clinical imaging, medical physics, and radiation therapy.
His recent works focus on:
- The implementation and commissioning of novel instrumentation for real time treatment monitoring for stereotactic radiotherapy, brachytherapy, and intensity modulated radiotherapy.
- The development of image guided cell micro irradiator for nano irradiation to study the complex interaction of chemotherapeutic drugs and radiotherapy in cancer cells in a controlled microenvironment.
- Studies designed to determine the therapeutic efficacy of new drugs for gliomas and phase contrast imaging to detect radiation induced complications in lung tissue.
To view Dr. Izaguirre’s most recent publications, click here.